From Literature

Science is useful when read with care. Here we gather the papers that inform how we think about nutrients, ingredient forms and formulation. We prefer evidence to assertion, and context to convenient conclusions.

  • Why D3?

    Heaney R.P. et al. · Journal of Clinical Endocrinology & Metabolism · 2011

    A randomized human study comparing vitamin D3 with vitamin D2 in healthy adults and examining their ability to raise and maintain serum 25-hydroxyvitamin D.

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  • K2VITAL® in human research

    Møller M. et al. · International Journal for Vitamin and Nutrition Research · 2017

    A randomized human study examining the bioavailability and biological activity of K2VITAL® MK-7 in healthy adults.

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  • MK-7 and bone health

    Knapen M.H.J. et al. · Osteoporosis International · 2013

    A three year randomized controlled trial examining MK-7 supplementation, vitamin K status and measures of bone density and bone strength in healthy postmenopausal women.

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  • MK-7 and vitamin K status

    Theuwissen E. et al. · Food & Function · 2014

    A study of healthy volunteers examining extrahepatic vitamin K status and the response of vitamin K dependent biomarkers to MK-7 supplementation.

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Vitamin D and Vitamin K

Kuang X. et al. · Food & Function · 2020

A meta analysis of randomized controlled trials examining vitamin K and vitamin D together in relation to bone mineral density and vitamin K dependent bone markers.

Magnesium

Magnesium Bisglycinate and Magnesium Oxide

Schuette S.A. et al. · Journal of Parenteral and Enteral Nutrition · 1994

A randomized, double-blind crossover study comparing magnesium bisglycinate and magnesium oxide in individuals with impaired intestinal absorption following ileal resection.

Comparative Absorption of Magnesium Forms

Hartle J.W. et al. · The FASEB Journal · 2016
An in-vitro study using a Caco-2 intestinal cell model to compare magnesium transport across commonly used supplemental forms, including magnesium bisglycinate, citrate, and oxide.

  • Linus Pauling

    How to Live Longer and Feel Better

    An early and influential expression of orthomolecular thought. Pauling’s work forms part of the intellectual history behind the idea of considering nutrition at the molecular level.

  • Michael F. Holick, M.D., Ph.D.

    The Vitamin D Solution

    A widely read exploration of vitamin D, its physiology and the consequences of inadequate status. Holick’s work helped bring vitamin D from a familiar nutrient into a broader discussion of human health.

Further reading

This collection will continue to grow as we review the literature behind each nutrient and formulation.