Science is useful when read with care. Here we gather the papers that inform how we think about nutrients, ingredient forms and formulation. We prefer evidence to assertion, and context to convenient conclusions.
Vitamin D3
Why D3?
Heaney R.P. et al. · Journal of Clinical Endocrinology & Metabolism · 2011
A randomized human study comparing vitamin D3 with vitamin D2 in healthy adults and examining their ability to raise and maintain serum 25-hydroxyvitamin D.
Knapen M.H.J. et al. · Osteoporosis International · 2013
A three year randomized controlled trial examining MK-7 supplementation, vitamin K status and measures of bone density and bone strength in healthy postmenopausal women.
A meta analysis of randomized controlled trials examining vitamin K and vitamin D together in relation to bone mineral density and vitamin K dependent bone markers.
Schuette S.A. et al. · Journal of Parenteral and Enteral Nutrition · 1994
A randomized, double-blind crossover study comparing magnesium bisglycinate and magnesium oxide in individuals with impaired intestinal absorption following ileal resection.
Hartle J.W. et al. · The FASEB Journal · 2016 An in-vitro study using a Caco-2 intestinal cell model to compare magnesium transport across commonly used supplemental forms, including magnesium bisglycinate, citrate, and oxide.
An early and influential expression of orthomolecular thought. Pauling’s work forms part of the intellectual history behind the idea of considering nutrition at the molecular level.
Michael F. Holick, M.D., Ph.D.
The Vitamin D Solution
A widely read exploration of vitamin D, its physiology and the consequences of inadequate status. Holick’s work helped bring vitamin D from a familiar nutrient into a broader discussion of human health.
Further reading
This collection will continue to grow as we review the literature behind each nutrient and formulation.
THE PROMISE ROOTS NEWSLETTER
Explore the essential nutrients, ingredient origins, and the making of Promise Roots. Be the first to know when the Daily Essentials System arrives in Autumn 2026.
Choosing a selection results in a full page refresh.